Inhibitory Effect of Amantadine Hydrochloride on Bovine Virus Diarrhea and SF-4 Viruses
Chatham County (Ga.)
African American universities and colleges--Georgia—Savannah
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AbstractCertain myxoviruss and several strains of human influenza and parainfluenza viruses are inhibited by amantadine hydrochloride (1-adamantanamine hydrochloride) both in vitro and in vivo. 1, 2, 5 The evaluation of amantadine in the prevention of influenza in humans has been discussed. Other viruses, such as rubella, pseudorabies, and fowl plague viruses are also sensitive to this drug.3, 4 Recently, the drug was shown to inhibit murine sarcoma viruses in cell cultures. The effect of amantadine hydrocloride on the multiplication of bovine virus diarrhea (BVD) and SF-4 (bovine myxovirus parainfluenza-3) viruses in primary bovine embryonic kidney (BEK) cell culture are presented in this report.
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